5,406
edits
Difference between revisions of "High Pressure Homogenizers"
Jump to navigation
Jump to search
High Pressure Homogenizers (view source)
Revision as of 06:46, 25 February 2022
, 06:46, 25 February 2022→The future of high pressure homogenizers
| (4 intermediate revisions by the same user not shown) | |||
| Line 47: | Line 47: | ||
===Hand Driven=== | ===Hand Driven=== | ||
[[File:High_Pressure_Homogenizers_handdriven.png|thumb|250px|right|Hand-driven high pressure homogenizer]] | [[File:High_Pressure_Homogenizers_handdriven.png|thumb|250px|right|Hand-driven high pressure homogenizer]] | ||
Hand driven homogenizers<ref> pressurize the material by manual power. The flow rate of a hand homogenizer is small, but it is portable and easy to assemble and disassemble. It requires very small amounts of materials, making it suitable for small-scale experiments. This type of device is capable of supporting biopharmaceutical laboratories’ research and development needs. The manual high-pressure homogenizer is also called the Handgenizer.1 | Hand driven homogenizers<ref>HandGenizer,[https://www.genizer.com/handgenizer-laboratory-hand-drive_p0009.html]</ref> pressurize the material by manual power. The flow rate of a hand homogenizer is small, but it is portable and easy to assemble and disassemble. It requires very small amounts of materials, making it suitable for small-scale experiments. This type of device is capable of supporting biopharmaceutical laboratories’ research and development needs. The manual high-pressure homogenizer is also called the Handgenizer.1 | ||
===Air Driven=== | ===Air Driven=== | ||
| Line 54: | Line 54: | ||
==By principle and structure of the interaction chamber== | ==By principle and structure of the interaction chamber== | ||
[[File:High_Pressure_Homogenizers_principle.png|thumb| | [[File:High_Pressure_Homogenizers_principle.png|thumb|300px|right|The three-type principle of high pressure homogenization<ref>Three-Types Homogenizing Mechanism in History. [https://www.genizer.com/art/technology_a0043.html]</ref>]] | ||
===First Generation: Impact Type=== | ===First Generation: Impact Type=== | ||
| Line 94: | Line 94: | ||
[[File:High_Pressure_Homogenizers_Ceramic_piston.png|thumb|250px|right|Ceramic piston]] | [[File:High_Pressure_Homogenizers_Ceramic_piston.png|thumb|250px|right|Ceramic piston]] | ||
Overall, a cylinder with an intensifier is superior to a direct-drive one. | Overall, a cylinder with an intensifier is superior to a direct-drive one. | ||
Under the same flow rate, higher pressure produces lower frequency, fewer pressure fluctuations, better product quality, and greater equipment durability. At 30,000 psi, a laboratory high pressure homogenizer, can reach fluctuation levels of less than 10 Hz, as opposed to 60 Hz from a normal homogenizer. | Under the same flow rate, higher pressure produces lower frequency, fewer pressure fluctuations, better product quality, and greater equipment durability. At 30,000 psi, a laboratory high pressure homogenizer<ref>NanoGenizer, [https://www.genizer.com/nanogenizer_p0039.html]</ref>, can reach fluctuation levels of less than 10 Hz, as opposed to 60 Hz from a normal homogenizer. | ||
High pressure piston materials can be divided into ceramics, tungsten carbide, and hardened stainless steel, with ceramics as the costliest option and hardened stainless steel as the most affordable. Quality and durability align with cost: Ceramic materials offer the highest quality, followed by hard tungsten alloy, with hardened stainless steel as a lower-quality option. | |||
==Selecting homogenization parts== | ==Selecting homogenization parts== | ||
| Line 113: | Line 112: | ||
=The future of high pressure homogenizers= | =The future of high pressure homogenizers= | ||
In 2010, the FDA announced a recall of eleven batches of clevidipine butyrate injection emulsion across the United States due to the possibility that the emulsion contained inert metallic particles. | In 2010, the FDA announced a recall of eleven batches of clevidipine butyrate injection emulsion across the United States due to the possibility that the emulsion contained inert metallic particles<ref>Recall -- Firm Press Release. FDA.[https://www.fda.gov/media/78662/download]</ref>. Particles gathering and forming larger particles would theoretically lead to clogging in blood capillaries, causing mechanical damage to the body or other acute or chronic inflammations. | ||
Therefore, it is not recommended to use the impact type of homogenization chamber in the pharmaceutical industry. These models are no longer suitable for mass production of pharmaceutical emulsion injection. The interaction mechanism is also more durable in ultra-high pressure machines when equipped with temperature control. With increasing demand for nanomaterials, which require higher pressure and higher performance in nano-dispersion, interaction chambers will be more widely used in nanotechnology fields, such as pharmaceuticals, semiconductors, and microelectronics. | Therefore, it is not recommended to use the impact type of homogenization chamber in the pharmaceutical industry. These models are no longer suitable for mass production of pharmaceutical emulsion injection. The interaction mechanism is also more durable in ultra-high pressure machines when equipped with temperature control. With increasing demand for nanomaterials, which require higher pressure and higher performance in nano-dispersion, interaction chambers will be more widely used in nanotechnology fields, such as pharmaceuticals, semiconductors, and microelectronics. | ||
| Line 120: | Line 119: | ||
With the development of the high thrust linear actuator system, high-thrust and low-speed linear motors will be applied in ultra-high pressure homogenizers in the future. As the pressure increases, temperature control will be a major technical challenge—and therefore, a temperature-controlled and ultra-high pressure-durable interaction chamber is a major avenue for future development. | With the development of the high thrust linear actuator system, high-thrust and low-speed linear motors will be applied in ultra-high pressure homogenizers in the future. As the pressure increases, temperature control will be a major technical challenge—and therefore, a temperature-controlled and ultra-high pressure-durable interaction chamber is a major avenue for future development. | ||
=Videos= | =Videos= | ||